関連施設等
奥山上席専門研究員が執筆したアミロイドPETの新しい解析法に関する論文が英文誌に掲載されました
- 日付2024-6-22
- 発行日2024.6.22 Epub ahead of print
- 雑誌名Ann Nucl Med doi: 10.1007/s12149-024-01956-y.
- 題名New objective simple evaluation methods of amyloid PET/CT using whole-brain histogram and Top20%-Map
- 執筆者Okuyama C, Higashi T, Ishizu K, Oishi N, Kusano K, Ito M, Kagawa S,Okina T, Suzuki N, Hasegawa H, Nagahama Y, Watanabe H, Ono M, Yamauchi H.
- 要旨Objective: This study aims to assess the utility of newly developed objective methods for the evaluation of intracranial abnormal amyloid deposition using PET/CT histogram without use of cortical ROI analyses.
- Methods: Twenty-five healthy volunteers (HV) and 38 patients with diagnosed or suspected dementia who had undergone 18F-FPYBF-2 PET/CT were retrospectively included in this study. Out of them, 11C-PiB PET/CT had been also performed in 13 subjects. In addition to the
- conventional methods, namely visual judgment and quantitative analyses using composed standardized uptake value ratio (comSUVR), the PET images were also evaluated by the following new parameters: the skewness and the mode-to-mean ratio (MMR) obtained
- rom the histogram of the brain parenchyma； Top20%-map highlights the areas with high tracer accumulation occupying 20% volume of the total brain parenchymal on the individual’s CT images.
- We evaluated the utility of the new methods using histogram compared with the visual assessment and comSUVR. The results of these new methods between 18F-FPYBF-2 and 11C-PiB were also compared in 13 subjects.
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